3/31/2024 0 Comments Iaea-tecdoc-1188Prior to use, the lyophilized mixture is reconstituted with sodium pertechnetate ( 99mTc) and boiled to form technetium ( 99mTc) Sestamibi. The kit includes a lyophilized mixture of a copper complex of MIBI (tetrakis(2-methoxyisobutylisonitrile)copper(I) tetrafluoroborate (BF 4)) as the active ingredient, sodium citrate dihydrate as a buffer, L-cysteine hydrochloride monohydrate as a stabilization aid, mannitol as a lyophilization aid, and stannous chloride dihydrate as a reducing agent. Discovered in 1981 by Alan Davison, it received FDA approval in 1990 and it has been sold commercially since February 1991. This radiopharmaceutical, which is commercially available in the form of a kit under the tradenames CARDIOLITE® and MIRALUMA®, is useful for detecting coronary artery disease as well as evaluating breast lesions by planar imaging. Methoxyisobutylisonitrile (MIBI) is a key starting material in the preparation of the complex technetium ( 99mTc) hexakis(2-methoxyisobutylisonitrile) (technetium ( 99mTc) Sestamibi). The present invention relates to new syntheses of 2-methoxyisobutylisonitrile and metal isonitrile complexes, such as tetrakis(2-methoxyisobutylisonitrile)copper(I) tetrafluoroborate, which are used in the preparation of technetium ( 99mTc) Sestamibi. 30, 2006, both of which are hereby incorporated by reference.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |